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課程名稱 |
高等化學生物學一
Advanced Chemical Biology (Ⅰ) |
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開課學期 |
105-1 |
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授課對象 |
理學院 化學所化學生物學組 |
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授課教師 |
戴桓青 |
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課號 |
Chem7037 |
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課程識別碼 |
223EM1660 |
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班次 |
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學分 |
4 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期一6,7(13:20~15:10)星期四6,7(13:20~15:10) |
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上課地點 |
化121化121 |
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備註 |
本課程以英語授課。限碩士生修習。
本班英文授課。
限碩士班以上 且 限本系所學生(含輔系、雙修生)
總人數上限：50人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1051Chem7037_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
This class will discuss various special topics at the interface of chemistry and biology.
1. Nucleic acid structure and synthesis
2. DNA sequencing and mimetics
3. RNA: RNA interference
4. Ribozymes and aptamers
5. Carbohydrates: structure
6. Carbohydrates: biosynthesis and function
7. Carbohydrates: applications
8. Carbohydrates: chemical synthesis
9. Introduction to lipids and membranes
10. Lipid structure
11. Protein synthesis and folding
12. Protein degradation and quality control
13. Protein misfolding and neurodegeneration
14. Producing proteins and peptides
15. Chromatography and electrophoresis
16. Protein extraction, subcellular fractionation, centrifugation
17. Antibody technologies
18. Humanized antibody
19. Structural Biology
20. Labeling with fluorophores and biotin
21. Fluorescent proteins and FRET
22. Basics of Fluorescence Microscopy
23. Super-resolution Optical Microscopy
24. Bioorthogonal chemistry; Active site probe
25. Mass spec: instrumentation
26. Mass spec of proteins
27. Mass spec and protein quantification
28. Post-translational modifications
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課程目標 |
Understand the chemical principles behind the materials and methods commonly encountered in modern biology labs. Apply chemical thinking to solve biological problems. |
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課程要求 |
待補 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
待補 |
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參考書目 |
"Essentials of Glycobiology" 2nd Edition, by Varki A., Cummings R.D., Esko
J.D., et al., editors.Cold Spring Harbor (NY): Cold Spring Harbor Laboratory
Press; 2009.
"Biochemistry" 7yh ed., by J. M. Berg, J. L. Tymocko and L. Stryer. Freeman, New York, 2012.
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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第1週 |
9/12,9/15 |
Mon: Introduction to chemical biology
Thu: National Holiday (Mid-Autumn Festival) |
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第2週 |
9/19,9/22 |
No class (HUPO 2016 conference) |
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第3週 |
9/26,9/29 |
Nucleic acid and DNA |
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第4週 |
10/03,10/06 |
RNA and ribozyme |
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第5週 |
10/10,10/13 |
Mon: National Holiday (Double Ten)
Thu: Protein and peptide synthesis |
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第6週 |
10/17,10/20 |
Mon: Protein transport and degradation
Thu: Carbohydrate structure |
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第7週 |
10/24,10/27 |
1. Carbohydrate function
2. Lipid part 1 |
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第8週 |
10/31,11/03 |
1. Lipid Structure
2. Antibody technology |
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第9週 |
11/07,11/10 |
11/7 bioorthogonal chemistry
11/10 KT Wang lecture (no class) |
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第10週 |
11/14,11/17 |
11/14 Midterm exam
11/17 Biomolecule separation |
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第11週 |
11/21,11/24 |
Protein mass spectrometry |
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第12週 |
11/28,12/01 |
11/28 Protein quantification by MS (Homework due)
12/1 Fluorescent dyes and proteins |
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第13週 |
12/05,12/08 |
12/5 Homework Grading Tutorial (Yu-Ting Tsai)
12/8 Fluorescence microscopy |
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第14週 |
12/12,12/15 |
12/12 Electron microscopy and super-resolution imaging
12/15 Protein Folding and Misfolding (Prof. Chen) |
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第15週 |
12/19,12/22 |
12/19 Homework grading due
Protein Folding and Misfolding (Prof. Chen) |
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第16週 |
12/26,12/29 |
Structural Biology (Prof. Ho) |
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第17週 |
1/02,1/05 |
1/2 New Year Holiday (no class)
1/5 Structural Biology (Prof. Ho) |
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